Explore UAB

banner reynolds 1900x200

Microbial antagonisms and antibiotic substances. New York: The Commonwealth Fund, 1945.

Selman Waksman (left)Ukranian-born American biochemist/microbiologist Selman Waksman immigrated to the United States from Russia in 1910 after being refused acceptance into college because of anti-Semitism. He received both B.Sc. and M.Sc. degrees from Rutgers University, and in 1918, he received a Ph.D. in biochemistry from the University of California. Upon completing his doctorate, Waksman returned to Rutgers and eventually became a full professor of soil microbiology in 1930. He held several other faculty positions at that university throughout the remainder of his career, including chairman of the microbiology department and director of the Rutgers Institute of Microbiology.

As a soil microbiology specialist, Waksman made it his goal to find what he called “antibiotics” in the soil micro-organisms called antinomycetes. In 1940, Waksman isolated an antibiotic called actinomycin from antinomycetes. Though actinomycin was effective in killing bacteria, it was toxic when used on animals. Although this made it unusable, the discovery of this antibiotic led Waksman in the right direction, and a few years later, he isolated streptomycin from another species of antinomycetes, Stretomyces griseus. This antibiotic had low toxicity, and Waksman found that it was useful in fighting tuberculosis (Porter 457-458). Tuberculosis had been the most significant cause of adult death in the late nineteenth century, but a vaccination developed in the 1920s reduced the disease’s spread (Duffin 157). However, Waksman’s antibiotic, along with chemotherapeutic treatments, helped to drastically reduce tuberculosis mortality in the twentieth century. He received a Nobel Prize for his discovery in 1952.

Waksman and his associates went on to extract several other valuable antibiotics from soil microorganisms. His 1945 book, Microbial antagonisms and antibiotic substances, is an in-depth study of the relationships of microorganisms, especially their antagonistic tendencies which aid in disease treatment (Waksman, Microbial antagonisms, viii). Though soil was Waksman’s primary research focus, it is not the only medium for microorganisms discussed in this book. The Reynolds-Finley Library holds a first edition copy of Microbial antagonisms and antibiotic substances.

Britann. Guide to the Nobel Prizes, Chambers, Concise Dict. Of Scientists, p.392; Duffin, Hist. of Med., pp.157, 159-160; Porter, Greatest Benefit to Mankind, pp.457-458; Rutgers University Archives and Special Collections; Reynolds Historical Library, Rare books and coll., Vol. 2, 2-1797.

Image: Selman Waksman, Pictured on the left, Courtesy of the National Library of Medicine.

Mervyn H. Sterne Library

917 13th St S
Birmingham, AL

(205) 934-6364

Lister Hill Library of the Health Sciences

1700 University Blvd
Birmingham, AL

(205) 975-4821

Reynolds-Finley Historical Library

1700 University Blvd - 3rd Floor
Birmingham, AL

(205) 934-4475

Alabama Museum of the Health Sciences

1700 University Blvd - 3rd Floor
Birmingham, AL

(205) 934-4475

Lister Hill Library at University Hospital

615 18th Street S - P235 West Pavilion
Birmingham, AL

(205) 934-2275

801 Building

801 5th Ave South
Room 1111
Birmingham, AL

(205) 934-5432

J. Ellis Sparks Medical Library

301 Governors Drive SE - 3rd Floor
Huntsville, AL 35801

(256) 551-4405

Back to Top